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Actionable DMPK data is essential at every stage of development

Understanding the disposition of your molecule and its drug metabolism & pharmacokinetic (DMPK) profile is critical to making the right decisions about your molecule and minimizing failures at every stage of development. Whether you're optimizing lead candidates, preparing for IND-enabling studies or managing clinical-stage assets, you need actionable data from reliable Absorption, Distribution, Metabolism, and Excretion (ADME) studies to guide you forward in a cost- and time-efficient way. Don’t get surprised by poor clinical exposure or a drug-drug interaction that can slow or halt the development of your small molecule, large molecule or biologic based pharmaceutical candidate.

Why choose Labcorp?

  • Multidisciplinary team with years of experience

  • Flexible solutions to meet any development strategy 

  • Programmatic metabolism model to save time and minimize failure

Better predict metabolism and pharmacokinetics of your molecule

Our DMPK support is designed to give you clear insight into your molecule's biotransformation and pharmacokinetic behavior. Using in vitro and in vivo metabolism studies, we help you:

Identify lead molecules and drug candidates that match your Target Product Profile

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Predict pharmacokinetics , understand biotransformation pathways and assess drug-drug interaction (DDI) risks before clinical trials

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Identify potential metabolic liabilities or safety concerns early

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Understand species-specific metabolism to inform your choice of preclinical models

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Integrate PK data across studies to guide dose selection and support regulatory submissions

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Use modeling and simulation tools to project human exposure and optimize trial design

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Whether you need bioanalytical support, PBPK modeling or comprehensive ADME studies, our scientists work alongside your team to build a customized strategy that aligns with your development goals.

With the right data, you can move faster, reduce risk and make critical decisions with confidence.

DMPK & ADME capabilities

 

In vivo metabolism

  • In Vivo Metabolism
  • Fast PK | PK/TK Analysis & Reporting
  • Radiolabeled ADME | hAME
  • Bioequivalcence | Biosimilars
  • WBA

MetID

  • Metabolite Identification (MetID)
  • Human AME
  • In Vitro / In Vivo Cross Species
  • Metabolic Stability
  • Radiolabeled ADME

Frequently asked questions

From early discovery to regulatory submission and beyond, our nonclinical development solutions help derisk your program, accelerate timelines, and optimize decision-making.